•  
     

    The #1 Gastroenterologist-

    Recommended Multi-StrainProbioticsBrand

    Trusted by healthcare professionals and millions of customers worldwide,

    VSL#3 is a gold standard in multi-strain probiotics - recommended by

    experts for quality, consistency, and proven performance.

    Shop Now

More Than a Probiotic.
A Powerful Medical Food.

Pioneers in Probiotics.
Leaders in Gut Health.

VSL#3® is an ultra-high-potency probiotic medicalfood - and the #1 gastroenterologist-recommended multi-strain probiotics brand.Developed for people with serious gastrointestinalconditions, it's trusted by healthcare professionalsand customers alike for its scientific foundation,clinical credibility, and unwavering quality.

VSL#3® is an ultra-high-potency probiotic medicalfood - and the #1 gastroenterologist-recommended multi-strain probiotics brand.Developed for people with serious gastrointestinalconditions, it's trusted by healthcare professionalsand customers alike for its scientific foundation,clinical credibility, and unwavering quality.

Built on Science.
Proven in Practice.

Driven by research - not marketing trends -VSL#3® is trusted in clinical care for the dietarymanagement of specific gastrointestinalconditions. It continues to set the standard forpotency, consistency, and reliability in probiotictherapy.

Driven by research - not marketing trends -VSL#3® is trusted in clinical care for the dietarymanagement of specific gastrointestinalconditions. It continues to set the standard forpotency, consistency, and reliability in probiotictherapy.

Built on Science.
Proven in Practice.

VSL#3® products deliver between 112.5 billionand 900 billion live bacteria per serving,depending on the formulation. Unlike manyprobiotics that only promise potency at the timeof manufacture, VSL#3® guarantees potencythrough expiration when stored as directed.

VSL#3® products deliver between 112.5 billionand 900 billion live bacteria per serving,depending on the formulation. Unlike manyprobiotics that only promise potency at the timeof manufacture, VSL#3® guarantees potencythrough expiration when stored as directed.

Clinically Researched Formulas.
Real-World Results.

Each VSL#3®product combines 8 well-characterized probiotic strains from 3 genera tohelp maintain a balanced intestinal microbiota andsupport digestive health. The VSL#3® family isspecially designed for the dietary management ofirritable bowel syndrome (IBS), ulcerative colitis(UC), and pouchitis.

Each VSL#3®product combines 8 well-characterized probiotic strains from 3 genera tohelp maintain a balanced intestinal microbiota andsupport digestive health. The VSL#3® family isspecially designed for the dietary management ofirritable bowel syndrome (IBS), ulcerative colitis(UC), and pouchitis.

  • Bifidobacterium

    Bifidobacterium breve,Bifidobacteriumlactis (previously classified as B.infantis), Bifidobacterium lactis(previously classified as B. longum)

  • Lactobacillus

    Lactobacillus acidophilus, Lactobacillus
    helveticus (previously classified as L.delbrueckii.subsp.bulgaricus),Lactobacillus paracasei, Lactobacillusplantarum

  • Streptococcus

    Streptococcus thermophilus

    previously classified as Streptococcus salivarius subsp. thermophilus,formerly referenced as Streptococcus bulgaricus.

    Our Purpose: ScienceThat Serves People

    Microbiome health isn't one-size-fits-all - and neither are we.

    VSL® Probiotics exists to bridge the gap between scientific discovery andeveryday wellbeing. We develop precision-formulated probiotics groundedin a legacy of microbiome research, helping people manage complexdigestive conditions and support their daily gut and vaginal health.

    From VSL#3®, a gold-standard medical food trusted by healthcare professionals and customers worldwide, we're guided by one goal: to empower better health through probiotic science that delivers real-world results.

    Our formulations are built on the highest standards of potency, quality, andreliability. Backed by scientific and clinical research, VSL®Probioticscontinues to lead the way in advancing microbiome science for both clinicall use and everyday wellness.

    The VSL®Difference:Proven. Precise.Trusted.

    VSL®Probiotics builds on the legacy of VSL#3® a formulationtrusted by healthcare professionals for its quality, consistency, andreliability. That same foundation guides every product in the VSLRProbiotics family, from clinically studied medical foods to precision-formulated daily supplements.

    Our focus remains the same: creating probiotic formulationsgrounded in evidence, crafted with precision, and respected fortheir consistency - not driven by trends, but by trust earned
    through experience.

    FAQS

    What is VSL#3®?

    VSL#3® is an ultra-high-potency probiotic medical food intended for the dietarymanagement of irritable bowel syndrome (IBS), ulcerative colitis (UC), and an ileal pouch(pouchitis).

    How should I store VSL#3®?

    VSL#3® should be stored under refrigeration at 36-46°F (2-8°C) to preserve potency. Itcan remain at room temperature for up to 2 weeks without reducing effectiveness.

    What is a Medical Food?

    Medical foods are formulated for the dietary management of diseases or conditions withdistinctive nutritional needs that cannot be met by diet alone. Unlike dietarysupplements, medical foods are intended for use under a healthcare provider's
    supervision.

    How does VSL#3® compare to a Low FODMAP diet for IBSmanagement?

    In a 2021 clinical study, VSL#3® demonstrated dietary management outcomes in peoplewith IBS comparable to those achieved with a low FODMAP diet1 - a commonlyrecommended but restrictive approach. Because VSL#3® is certified FODMAP Friendly, it can also be used alongside a low FODMAP diet for flexible dietary management.

    1Ankerson L, et al. J Med Internet Res. 2021; 23(12): e30291.

    How are VSL#3® and VSL4R Gut different?

    Although both products contain the same 8 probiotic strains, they are formulated andlabeled for different purposes. VSL#3
    ®is a refrigerated, ultra-high-potency probioticmedical food for the dietary management of specific GI conditions. VSL4® Gut is aprobiotic supplement designed to support digestive comfort, regularity, and overall guthealth.*